ARP 101

Name: ARP 101
Brand: Tocris Bioscience
SKU: 2622

Tocris Bioscience, part of Bio-Techne | Catalog # 2622

Citations (15)

COA / SDS

Inhibitor of MMP-2

Key Product Details

Description:	Inhibitor of MMP-2
Chemical Name:	(R)-N-Hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamide
Purity:	≥99% (HPLC)
Molecular Weight:	406.5

View Full Technical Details for ARP 101

Technical Data
Citations

Biological Activity for ARP 101

ARP 101 is a selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC₅₀ values are 0.81 and 486 nM respectively).

Technical Data for ARP 101

M. Wt	406.5
Formula	C₂₀H₂₆N₂O₅S
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	849773-63-3
PubChem ID	11292680
InChi Key	DGZZVIWCMGVHGV-LJQANCHMSA-N
Smiles	O=S(C1=CC=C(C2=CC=CC=C2)C=C1)(N(OC(C)C)[C@H]([C@@H](C)C)C(NO)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ARP 101

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.65	100
	ethanol	10.16	25

Preparing Stock Solutions for ARP 101

The following data is based on the product molecular weight 406.5.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.30 mL	24.60 mL
5 mM	0.49 mL	2.46 mL	4.92 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for ARP 101

References are publications that support the biological activity of the product.

Tuccinardi Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3 methylbutanamides. Bioorg.Med.Chem. 2006 PMID: 16483784