ARRY 520 trifluoroacetate

Name: ARRY 520 trifluoroacetate
Brand: Tocris Bioscience
SKU: 4676
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 4676

(1)

Citations (1)

COA / SDS

Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation

Key Product Details

Description:	Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
Alternative Names:	Filanesib
Chemical Name:	(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate
Purity:	≥98% (HPLC)
Molecular Weight:	420.48

View Full Technical Details for ARRY 520 trifluoroacetate

Technical Data
Citations / Reviews (1)

Biological Activity for ARRY 520 trifluoroacetate

ARRY 520 trifluoroacetate is a potent kinesin spindle protein (KSP) inhibitor (IC₅₀ = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μM. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo.

Technical Data for ARRY 520 trifluoroacetate

M. Wt	420.48
Formula	C₂₀H₂₂F₂N₄O₂S.CF₃CO₂H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1781834-99-8
PubChem ID	90488964
InChi Key	CIJUJPVFECBUKG-BDQAORGHSA-N
Smiles	FC1=CC=C(F)C=C1C2=NN(C(N(C)OC)=O)[C@](CCCN)([C@]3=CC=CC=C3)S2.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ARRY 520 trifluoroacetate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	31.54	75
	ethanol	31.54	75

Preparing Stock Solutions for ARRY 520 trifluoroacetate

The following data is based on the product molecular weight 420.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.75 mM	3.17 mL	15.85 mL	31.71 mL
3.75 mM	0.63 mL	3.17 mL	6.34 mL
7.5 mM	0.32 mL	1.59 mL	3.17 mL
37.5 mM	0.06 mL	0.32 mL	0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for ARRY 520 trifluoroacetate

References are publications that support the biological activity of the product.

Tunquist Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor cells treated with the kinesin spindle protein inhibitor ARRY-520. Mol.Cancer.Ther. 2010 PMID: 20571074
Kim KSP inhibitor ARRY-520 as a substitute for PacT. in type I ovarian cancer cells. J.Transl.Med. 2009 PMID: 19619321
Woessner ARRY-520, a novel KSP inhibitor with potent activity in hematological and taxane-resistant tumor models. Anticancer Res. 2009 PMID: 20032381