Artemether

Name: Artemether
Brand: Tocris Bioscience
SKU: 6818

Tocris Bioscience, part of Bio-Techne | Catalog # 6818

COA / SDS

Antimalarial; also inhibits neuroinflammation

Key Product Details

Description:	Antimalarial; also inhibits neuroinflammation
Chemical Name:	(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin
Purity:	≥98% (HPLC)
Molecular Weight:	298.37

View Full Technical Details for Artemether

Technical Data
Citations

Biological Activity for Artemether

Artemether is an antimalarial. Prevents cerebral malaria in Plasmodium berghei infected mice. Exhibits synergistic effects with Methylene Blue (Cat. No. 3213) against P. falciparum in vitro. Inhibits neuroinflammation in neuronal/microglial cell co-cultures via induction of Nrf2 expression.

Technical Data for Artemether

M. Wt	298.37
Formula	C₁₆H₂₆O₅
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	71963-77-4
PubChem ID	68911
Smiles	[H][C@@]12CC[C@H]([C@@]3(CC[C@]4(OO[C@@]13[C@](O[C@@H]([C@@H]2C)OC)(O4)[H])C)[H])C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Artemether

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.84	100
	ethanol	29.84	100

Preparing Stock Solutions for Artemether

The following data is based on the product molecular weight 298.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.35 mL	16.76 mL	33.52 mL
5 mM	0.67 mL	3.35 mL	6.70 mL
10 mM	0.34 mL	1.68 mL	3.35 mL
50 mM	0.07 mL	0.34 mL	0.67 mL

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Reconstitution Calculator

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References for Artemether

References are publications that support the biological activity of the product.

Prada Upregulation of reactive oxygen and nitrogen intermediates in Plasmodium berghei infected mice after rescue therapy with chloroquine or artem. J.Antimicrob.Chemother. 1996 PMID: 8858461
Akoachere In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins. Antimicrob.Agents Chemother. 2005 PMID: 16251300
Okorji Antimalarial drug artem. inhibits neuroinflammation in BV2 microglia through Nrf2-dependent mechanisms. Mol.Neurobiol. 2015 PMID: 26607631