AS 2444697

Name: AS 2444697
Brand: Tocris Bioscience
SKU: 5430
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5430

(3)

Citations (9)

COA / SDS

Potent and selective IRAK4 inhibitor

Key Product Details

Chemical Name:	N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
Purity:	≥98%

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Technical Data
Citations / Reviews (3)

Biological Activity for AS 2444697

AS 2444697 is a potent and selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor (IC₅₀ = 21 nM). Displays 30-fold selectivity for IRAK4 over IRAK1. Inhibits LPS-induced TNF-α and IL-6 production in PBMCs in vitro. Renoprotective and anti-inflammatory in a rodent model of chronic kidney disease.

Technical Data for AS 2444697

Formula	C₁₉H₂₀N₆O₄.HCl
Storage	Desiccate at RT
Purity	≥98%
CAS Number	1287665-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AS 2444697

Solubility

Soluble Soluble to 20 mM in DMSO with gentle warming

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References for AS 2444697

References are publications that support the biological activity of the product.

Chaudhary Recent advances in the discovery of small molecule inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4) as a therapeutic target for inflammation and oncology disorders. J.Med.Chem., 2015;58:96 PMID: 25479567
Kondo et al. Renoprotective effects of novel interleukin-1 receptor-associated kinase 4 inhibitor AS2444697 through anti-inflammatory action in 5/6 nephrectomized rats. Naunyn Schmiedebergs Arch.Pharmacol., 2014;387:909 PMID: 25052043
Schmaderer and Heemann Blocking innate immunity to slow the progression of chronic kidney disease. Naunyn Schmiedebergs Arch.Pharmacol., 2014;387:905 PMID: 25107563

AS 2444697

Tocris Bioscience, part of Bio-Techne | Catalog # 5430

Key Product Details

Biological Activity for AS 2444697

Technical Data for AS 2444697

Solubility for AS 2444697

Dilution Calculator

Reconstitution Calculator

References for AS 2444697

Product Documents for AS 2444697

COA

Certificate of Analysis

SDS

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