Asenapine maleate

Name: Asenapine maleate
Brand: Tocris Bioscience
SKU: 3737

Tocris Bioscience, part of Bio-Techne | Catalog # 3737

Citations (7)

COA / SDS

Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent

Key Product Details

Description:	Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent
Chemical Name:	(3aR,12bR)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
Purity:	≥98% (HPLC)
Molecular Weight:	401.84

View Full Technical Details for Asenapine maleate

Technical Data
Citations

Biological Activity for Asenapine maleate

Asenapine maleate is a novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pK_i values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT_1A, 5-HT_1B, 5-HT_2A, 5-HT_2B, 5-HT_2C, 5-HT_5A, 5-HT₆, 5-HT₇, D₁, D_2L, D_2S, D₃, D₄, α_1A, α_2A, α_2B, α_2C, H₁ and H₂ receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy.

Compound Libraries for Asenapine maleate

Asenapine maleate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Asenapine maleate

M. Wt	401.84
Formula	C₁₇H₁₆ClNO.C₄H₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	85650-56-2
PubChem ID	73416848
InChi Key	QGBIWSABMNWWNB-FGYPTBLJSA-N
Smiles	CN2C[C@]1([H])C3=C(C=CC=C3)OC4=C(C=C(Cl)C=C4)[C@]([H])1C2.CN6C[C@@]5([H])C7=C(C=CC=C7)OC8=C(C=C(Cl)C=C8)[C@@]([H])5C6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Asenapine maleate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.18	100
	ethanol	20.09	50

Preparing Stock Solutions for Asenapine maleate

The following data is based on the product molecular weight 401.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.44 mL	24.89 mL
5 mM	0.50 mL	2.49 mL	4.98 mL
10 mM	0.25 mL	1.24 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for Asenapine maleate

References are publications that support the biological activity of the product.

Meltzer Asenapine. Nat.Rev.Drug Discov. 2009 PMID: 19876039
Marston Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacol. 2009 PMID: 19462162
Shahid Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J.Psychopharmacol. 2009 PMID: 18308814