ASP 3026

Name: ASP 3026
Brand: Tocris Bioscience
SKU: 5310

Tocris Bioscience, part of Bio-Techne | Catalog # 5310

Citations (1)

COA / SDS

Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor

Key Product Details

Description:	Potent anaplastic lymphoma kinase (ALK) inhibitor; also potent ACK inhibitor
Chemical Name:	N²-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
Purity:	≥99% (HPLC)
Molecular Weight:	580.74

View Full Technical Details for ASP 3026

Technical Data
Citations

Biological Activity for ASP 3026

ASP 3026 is a potent anaplastic lymphoma kinase (ALK) inhibitor (IC₅₀ = 3.5 nM). Also inhibits Ack and ROS1 activity (IC₅₀ values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK⁺ T cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Suppresses tumor growth of NPM-ALK⁺ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.

Compound Libraries for ASP 3026

ASP 3026 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for ASP 3026

M. Wt	580.74
Formula	C₂₉H₄₀N₈O₃S
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	1097917-15-1
PubChem ID	25134326
InChi Key	MGGBYMDAPCCKCT-UHFFFAOYSA-N
Smiles	CN1CCN(C2CCN(C3=CC=C(NC4=NC(NC5=C(S(C(C)C)(=O)=O)C=CC=C5)=NC=N4)C(OC)=C3)CC2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ASP 3026

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	11.61	20

Preparing Stock Solutions for ASP 3026

The following data is based on the product molecular weight 580.74.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.61 mL	43.05 mL	86.10 mL
1 mM	1.72 mL	8.61 mL	17.22 mL
2 mM	0.86 mL	4.30 mL	8.61 mL
10 mM	0.17 mL	0.86 mL	1.72 mL

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References for ASP 3026

References are publications that support the biological activity of the product.

Awad and Shaw ALK Inhibitors in Non-Small Cell Lung Cancer: Crizotinib and Beyond. Clin.Adv.Hematol.Oncol. 2014 PMID: 25322323
Mori The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice. Mol.Cancer Ther. 2014 PMID: 24419060
George The ALK inhibitor ASP3026 eradicates NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget 2014 PMID: 25026277