ASP 7663

Name: ASP 7663
Brand: Tocris Bioscience
SKU: 5178

Tocris Bioscience, part of Bio-Techne | Catalog # 5178

Citations (5)

COA / SDS

Selective TRPA1 activator

Key Product Details

Description:	Selective TRPA1 activator
Chemical Name:	(2E)-2-[7-Fluoro-1,2-dihydro-1-(2-methylpropyl)-2-oxo-3H-indol-3-ylidene]acetic acid
Purity:	≥98% (HPLC)
Molecular Weight:	263.26

View Full Technical Details for ASP 7663

Technical Data
Citations

Biological Activity for ASP 7663

ASP 7663 is a selective TRPA1 activator (EC₅₀ values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable.

Technical Data for ASP 7663

M. Wt	263.26
Formula	C₁₄H₁₄FNO₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1190217-35-6
PubChem ID	44232532
InChi Key	RCVZUIGCNAAMIC-UXBLZVDNSA-N
Smiles	O=C2/C(C1=CC=CC(F)=C1N2CC(C)C)=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ASP 7663

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	26.33	100
	ethanol	26.33	100

Preparing Stock Solutions for ASP 7663

The following data is based on the product molecular weight 263.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.80 mL	18.99 mL	37.99 mL
5 mM	0.76 mL	3.80 mL	7.60 mL
10 mM	0.38 mL	1.90 mL	3.80 mL
50 mM	0.08 mL	0.38 mL	0.76 mL

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References for ASP 7663

References are publications that support the biological activity of the product.

Kojima Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur.J.Pharmacol. 2014 PMID: 24291101