AZ 11645373

Name: AZ 11645373
Brand: Tocris Bioscience
SKU: 3317

Tocris Bioscience, part of Bio-Techne | Catalog # 3317

Citations (30)

COA / SDS

Potent and selective human P2X7 antagonist

Key Product Details

Description:	Potent and selective human P2X₇ antagonist
Chemical Name:	3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
Purity:	≥98% (HPLC)
Molecular Weight:	463.51

View Full Technical Details for AZ 11645373

Technical Data
Citations

Biological Activity for AZ 11645373

AZ 11645373 is a potent and selective human P2X₇ antagonist (K_B values are 5 - 7 and > 10,000 nM at hP2X₇ and rP2X₇ respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1β release in vitro (K_B values are 15 and 92 nM respectively).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Technical Data for AZ 11645373

M. Wt	463.51
Formula	C₂₄H₂₁N₃O₅S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	227088-94-0
PubChem ID	9804433
InChi Key	VQEHBLGYANQWEA-UHFFFAOYSA-N
Smiles	O=C(CSC4=O)N4C(COC2=CC=C(C3=CC=CC([N+]([O-])=O)=C3)C=C2)CCC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 11645373

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.64	10

Preparing Stock Solutions for AZ 11645373

The following data is based on the product molecular weight 463.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.57 mL	107.87 mL	215.75 mL
0.5 mM	4.31 mL	21.57 mL	43.15 mL
1 mM	2.16 mL	10.79 mL	21.57 mL
5 mM	0.43 mL	2.16 mL	4.31 mL

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References for AZ 11645373

References are publications that support the biological activity of the product.

Michel Mechanism of action of species-selective P2X(7) receptor antagonists. Br.J.Pharmacol. 2009 PMID: 19309360
Alcaraz Novel P2X₇ receptor antagonists. Bioorg.Med.Chem.Letts.
Stokes Characterization of a selective and potent antagonist of human P2X₇ receptors, AZ11645373. Br.J.Pharmacol. 2006 PMID: 17031385