AZ 13705339

Name: AZ 13705339
Brand: Tocris Bioscience
SKU: 6177
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6177

Citations (3)

COA / SDS

Highly potent PAK1 and PAK2 inhibitor

Key Product Details

Description:	Highly potent PAK1 and PAK2 inhibitor
Chemical Name:	2-[[[2-[[3-(Ethylsulfonyl)-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-fluoro-4-pyrimidinyl][5-(hydroxymethyl)-2-methylphenyl]amino]methyl]benzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	629.75

View Full Technical Details for AZ 13705339

Technical Data
Citations

Biological Activity for AZ 13705339

AZ 13705339 is a highly potent PAK1 and PAK2 inhibitor (IC₅₀ values are 0.33 and 6 nM for PAK1 and PAK2, respectively). Displays >7500-fold selectivity for PAK1 over PAK4 (IC₅₀ = 2.6 μM).

Compound Libraries for AZ 13705339

AZ 13705339 is also offered as part of the Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ 13705339

M. Wt	629.75
Formula	C₃₃H₃₆FN₇O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2016806-57-6
PubChem ID	129909860
InChi Key	WPFLVPJXKWCRQK-UHFFFAOYSA-N
Smiles	CCS(=O)(C1=C(N2CCN(CC2)C)C=CC(NC3=NC=C(C(N(C4=CC(CO)=CC=C4C)CC5=C(C#N)C=CC=C5)=N3)F)=C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 13705339

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	62.98	100
	ethanol	12.6	20 with gentle warming

Preparing Stock Solutions for AZ 13705339

The following data is based on the product molecular weight 629.75.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.59 mL	7.94 mL	15.88 mL
5 mM	0.32 mL	1.59 mL	3.18 mL
10 mM	0.16 mL	0.79 mL	1.59 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for AZ 13705339

References are publications that support the biological activity of the product.

McCoull Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors. ACS Med.Chem.Lett. 2016 PMID: 27994749