AZ 628

Name: AZ 628
Brand: Tocris Bioscience
SKU: 4836

Tocris Bioscience, part of Bio-Techne | Catalog # 4836

Citations (5)

COA / SDS

Potent Raf kinase inhibitor

Key Product Details

Chemical Name:	3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide
Purity:	≥98%

View Full Technical Details for AZ 628

Technical Data
Citations

Biological Activity for AZ 628

AZ 628 is a potent, ATP-competitive inhibitor of Raf kinases (IC₅₀ values are 29, 34 and 105 nM for c-Raf1, B-Raf^V600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-Raf^V600E mutation.

Technical Data for AZ 628

Formula	C₂₇H₂₅N₅O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	878739-06-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ 628

Solubility

Soluble Soluble to 100 mM in DMSO

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References for AZ 628

References are publications that support the biological activity of the product.

Hatzivassiliou et al. RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature, 2010;464:431 PMID: 20130576
Montagut et al. Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res., 2008;68:4853 PMID: 18559533
Khazak et al. Selective Raf inhibition in cancer therapy. Expert Opin.Ther.Targets, 2007;11:1587 PMID: 18020980

AZ 628

Tocris Bioscience, part of Bio-Techne | Catalog # 4836

Key Product Details

Biological Activity for AZ 628

Technical Data for AZ 628

Solubility for AZ 628

Dilution Calculator

Reconstitution Calculator

References for AZ 628

Product Documents for AZ 628

COA

Certificate of Analysis

SDS

CONTACT INFORMATION

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