AZ PFKFB3 67

Name: AZ PFKFB3 67
Brand: Tocris Bioscience
SKU: 5742

Tocris Bioscience, part of Bio-Techne | Catalog # 5742

Citations (8)

COA / SDS

Potent and selective PFKFB3 inhibitor

Key Product Details

Description:	Potent and selective PFKFB3 inhibitor
Chemical Name:	(2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	455.51

View Full Technical Details for AZ PFKFB3 67

Technical Data
Citations

Biological Activity for AZ PFKFB3 67

AZ PFKFB3 67 is a potent and selective PFKFB3 inhibitor (IC₅₀ values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively).

Compound Libraries for AZ PFKFB3 67

AZ PFKFB3 67 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZ PFKFB3 67

M. Wt	455.51
Formula	C₂₆H₂₅N₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1704741-11-6
PubChem ID	91668554
InChi Key	NDIKFKQBWGMLCA-DEOSSOPVSA-N
Smiles	N#CC1=CN(CC2=C(C)ON=C2C)C3=C1C=C(OC4=CC=C(NC([C@H]5NCCC5)=O)C=C4)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZ PFKFB3 67

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.55	100
	ethanol	45.55	100

Preparing Stock Solutions for AZ PFKFB3 67

The following data is based on the product molecular weight 455.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	10.98 mL	21.95 mL
5 mM	0.44 mL	2.20 mL	4.39 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for AZ PFKFB3 67

References are publications that support the biological activity of the product.

Boyd Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 2015 PMID: 25849762