AZD 2066

Name: AZD 2066
Brand: Tocris Bioscience
SKU: 5614

Tocris Bioscience, part of Bio-Techne | Catalog # 5614

Citations (1)

COA / SDS

mGlu5 antagonist; orally bioavailable and brain penetrant

Key Product Details

Description:	mGlu₅ antagonist; orally bioavailable and brain penetrant
Chemical Name:	4-[5-[(1R)-1-[5-(3-Chlorophenyl)-3-isoxazolyl]ethoxy]-4-methyl-4H-1,2,4-triazol-3-yl]pyridine
Purity:	≥98% (HPLC)
Molecular Weight:	381.82

View Full Technical Details for AZD 2066

Technical Data
Citations

Biological Activity for AZD 2066

AZD 2066 is an mGlu₅ antagonist. Displays discriminative effects in rats. Orally bioavailable and brain penetrant.

Compound Libraries for AZD 2066

AZD 2066 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for AZD 2066

M. Wt	381.82
Formula	C₁₉H₁₆ClN₅O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	934282-55-0
PubChem ID	16041426
InChi Key	SXWHYTICXCLKDG-GFCCVEGCSA-N
Smiles	CN1C(C2=CC=NC=C2)=NN=C1O[C@H](C)C3=NOC(C4=CC=CC(Cl)=C4)=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 2066

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.18	100
	ethanol	38.18	100

Preparing Stock Solutions for AZD 2066

The following data is based on the product molecular weight 381.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.62 mL	13.10 mL	26.19 mL
5 mM	0.52 mL	2.62 mL	5.24 mL
10 mM	0.26 mL	1.31 mL	2.62 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for AZD 2066

References are publications that support the biological activity of the product.

Swedberg AZD9272 and AZD2066: selective and highly central nervous system penetrant mGluR₅ antagonists characterized by their discriminative effects. J.Pharmacol.Exp.Ther. 2014 PMID: 24876235