AZD 4547

Name: AZD 4547
Brand: Tocris Bioscience
SKU: 7823

Tocris Bioscience, part of Bio-Techne | Catalog # 7823

Citations (1)

COA / SDS

Potent and selective FGFR inhibitor

Key Product Details

Description:	Potent and selective FGFR inhibitor
Chemical Name:	rel-N-[5-[2-(3,5-Dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethyl-1-piperazinyl]benzamide
Purity:	≥98% (HPLC)
Molecular Weight:	463.56

View Full Technical Details for AZD 4547

Technical Data
Citations

Biological Activity for AZD 4547

AZD 4547 is a potent and selective FGFR1, FGFR3 and FGFR2 tyrosine kinase inhibitor (IC₅₀ values are 0.2 1.8, and 2.5 nM, respectively). It shows selectivity for FGFR across a range of unrelated tyrosine and serine/threonine kinases, including IGFR (>2,900-fold), CDK2 (>50,000-fold), and p38 (>50,000-fold). In vitro, it has antiproliferative effects on tumor cell lines with deregulated FGFR expression. In vivo, AZD 4547 exhibits dose-dependent inhibition of tumor growth in an FGFR-driven human tumor xenograft mice model. It suppresses osteoclastogenesis and tumor-induced osteolysis in an orthotopic breast cancer bone metastasis mouse model. AZD 4547 is orally bioavailable.

Technical Data for AZD 4547

M. Wt	463.56
Formula	C₂₆H₃₃N₅O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1035270-39-3
PubChem ID	51039095
InChi Key	VRQMAABPASPXMW-HDICACEKSA-N
Smiles	C[C@H]1CN(C2=CC=C(C=C2)C(NC3=NNC(CCC4=CC(OC)=CC(OC)=C4)=C3)=O)C[C@H](N1)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 4547

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.27	20

Preparing Stock Solutions for AZD 4547

The following data is based on the product molecular weight 463.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.79 mL	53.93 mL	107.86 mL
1 mM	2.16 mL	10.79 mL	21.57 mL
2 mM	1.08 mL	5.39 mL	10.79 mL
10 mM	0.22 mL	1.08 mL	2.16 mL

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References for AZD 4547

References are publications that support the biological activity of the product.

Kang A selective FGFR inhibitor AZD4547 suppresses RANKL/M-CSF/OPG-dependent ostoclastogenesis and breast cancer growth in the metastatic bone microenvironment. Sci.Rep. 2019 PMID: 31217507
Gavine AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family. Cancer Res. 2012 PMID: 22369928