AZD 7648

Name: AZD 7648
Brand: Tocris Bioscience
SKU: 7825

Tocris Bioscience, part of Bio-Techne | Catalog # 7825

COA / SDS

Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency

Key Product Details

Description:	Potent and selective DNA-PK inhibitor; enhances CRISPR-mediated HDR efficiency
Chemical Name:	7,9-Dihydro-7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5-a]pyridin-6-yl)amino]-9-(tetrahydro-2H-pyran-4-yl)-8H-purin-8-one
Purity:	≥98% (HPLC)
Molecular Weight:	380.41

View Full Technical Details for AZD 7648

Technical Data
Citations

Biological Activity for AZD 7648

AZD 7648 is a potent (IC₅₀= 0.6 nM in an enzyme assay) and selective DNA-PK inhibitor. It is selective for DNA-PK over a range of kinases including PI3Kα, PI3Kδ, PI3Kγ, ATM, ATR and mTOR. In combination with radiotherapy, it leads to tumor regression in fully immuno-competent mice models. It also enhances the activity of PARP inhibitor Olaparib (Cat. No. 7579). AZD 7648 is orally bioavailable. AZD 7648 also enhances CRISPR-mediated HDR efficiency.

Technical Data for AZD 7648

M. Wt	380.41
Formula	C₁₈H₂₀N₈O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2230820-11-6
PubChem ID	135151360
InChi Key	XISVSTPEXYIKJL-UHFFFAOYSA-N
Smiles	O=C1N(C)C2=CN=C(NC3=CN4N=CN=C4C=C3C)N=C2N1C5CCOCC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 7648

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.61	20

Preparing Stock Solutions for AZD 7648

The following data is based on the product molecular weight 380.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.14 mL	65.72 mL	131.44 mL
1 mM	2.63 mL	13.14 mL	26.29 mL
2 mM	1.31 mL	6.57 mL	13.14 mL
10 mM	0.26 mL	1.31 mL	2.63 mL

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References for AZD 7648

References are publications that support the biological activity of the product.

Wimberger Simultaneous inhibition of DNA-PK and Polθ improves integration efficiency and precision of genome editing. Nat.Commun. 2023 PMID: 37580318
Nakamura Inhibition of DNA-PK with AZD7648 sensitizes tumor cells to radiotherapy and induces type I IFN-dependent durable tumor control. Clin.Cancer Res. 2021 PMID: 34011558
Goldberg The discovery of 7-methyl-2-[(7-methyl[1,2,4]triazolo[1,5- a]pyridin-6-yl)amino]-9-(tetrahydro-2 H-pyran-4-yl)-7,9-dihydro-8 H-purin-8-one (AZD7648), a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. J.Med.Chem. 2020 PMID: 31851518
Fok AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity. Nat.Commun. 2019 PMID: 31699977