AZD 7762 hydrochloride

Name: AZD 7762 hydrochloride
Brand: Tocris Bioscience
SKU: 5199

Tocris Bioscience, part of Bio-Techne | Catalog # 5199

Citations (1)

COA / SDS

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

Key Product Details

Description:	Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing
Chemical Name:	3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	398.88

View Full Technical Details for AZD 7762 hydrochloride

Technical Data
Citations

Biological Activity for AZD 7762 hydrochloride

AZD 7762 hydrochloride is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC₅₀ vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo. Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 μM).

Licensing Information

Sold for research purposes under agreement from AstraZeneca

Compound Libraries for AZD 7762 hydrochloride

AZD 7762 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for AZD 7762 hydrochloride

M. Wt	398.88
Formula	C₁₇H₁₉FN₄O₂S.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1246094-78-9
PubChem ID	56972142
InChi Key	WFZBLOIXZRZEDG-YDALLXLXSA-N
Smiles	FC1=CC=CC(C2=CC(NC(N)=O)=C(C(N[C@@H]3CNCCC3)=O)S2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 7762 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	39.89	100
	DMSO	39.89	100

Preparing Stock Solutions for AZD 7762 hydrochloride

The following data is based on the product molecular weight 398.88.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.51 mL	12.54 mL	25.07 mL
5 mM	0.50 mL	2.51 mL	5.01 mL
10 mM	0.25 mL	1.25 mL	2.51 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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References for AZD 7762 hydrochloride

References are publications that support the biological activity of the product.

Morgan Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G₂ checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res. 2010 PMID: 20501833
Ma Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells. Nat Commun. 2018 PMID: 29610531
Zabludoff AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther. 2008 PMID: 18790776