AZD 7762 hydrochloride

Name: AZD 7762 hydrochloride
Brand: Tocris Bioscience
SKU: 5199

Tocris Bioscience, part of Bio-Techne | Catalog # 5199

Citations (1)

COA / SDS

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

Key Product Details

Chemical Name:	3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride
Purity:	≥98%

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Technical Data
Citations

Biological Activity for AZD 7762 hydrochloride

AZD 7762 hydrochloride is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC₅₀ vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo. Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 μM).

Technical Data for AZD 7762 hydrochloride

Formula	C₁₇H₁₉FN₄O₂S.HCl
Storage	Store at -20°C
Purity	≥98%
CAS Number	1246094-78-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 7762 hydrochloride

Solubility

Soluble Soluble to 100 mM in water and to 100 mM in DMSO

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References for AZD 7762 hydrochloride

References are publications that support the biological activity of the product.

Ma et al. Small molecules promote CRISPR-Cpf1-mediated genome editing in human pluripotent stem cells. Nat Commun., 2018;9:1303 PMID: 29610531
Zabludoff et al. AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies. Mol. Cancer Ther., 2008;7:2955 PMID: 18790776
Morgan et al. Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G₂ checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res., 2010;70:4972 PMID: 20501833

AZD 7762 hydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 5199

Key Product Details

Biological Activity for AZD 7762 hydrochloride

Technical Data for AZD 7762 hydrochloride

Solubility for AZD 7762 hydrochloride

Dilution Calculator

Reconstitution Calculator

References for AZD 7762 hydrochloride

Product Documents for AZD 7762 hydrochloride

COA

Certificate of Analysis

SDS

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