AZD 8055

Name: AZD 8055
Brand: Tocris Bioscience
SKU: 7840

Tocris Bioscience, part of Bio-Techne | Catalog # 7840

Citations (4)

COA / SDS

Highly potent and selective mTOR inhibitor

Key Product Details

Description:	Highly potent and selective mTOR inhibitor
Chemical Name:	5-[2,4-Bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Purity:	≥98% (HPLC)
Molecular Weight:	465.55

View Full Technical Details for AZD 8055

Technical Data
Citations

Biological Activity for AZD 8055

AZD 8055 is a highly potent, selective and ATP-competitive mTOR inhibitor (IC₅₀ = 0.8 nM). Inhibits growth and induces autophagy in a range of cancer cell lines and xenografts, including NSCLC and glioblastoma (IC₅₀ values are 20, 50 and 53 nM in H838, A549 and U87MG cell lines, respectively). Orally bioavailable.

Technical Data for AZD 8055

M. Wt	465.55
Formula	C₂₅H₃₁N₅O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1009298-09-2
PubChem ID	25262965
InChi Key	KVLFRAWTRWDEDF-IRXDYDNUSA-N
Smiles	C[C@@H]1N(CCOC1)C2=NC(N3[C@H](COCC3)C)=NC4=C2C=CC(C5=CC(CO)=C(C=C5)OC)=N4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for AZD 8055

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	46.55	100
	ethanol	9.31	20

Preparing Stock Solutions for AZD 8055

The following data is based on the product molecular weight 465.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.15 mL	10.74 mL	21.48 mL
5 mM	0.43 mL	2.15 mL	4.30 mL
10 mM	0.21 mL	1.07 mL	2.15 mL
50 mM	0.04 mL	0.21 mL	0.43 mL

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References for AZD 8055

References are publications that support the biological activity of the product.

Chresta AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mammalian target of rapamycin kinase inhibitor with in vitro and in vivo antitumor activity. Cancer Res. 2010 PMID: 20028854