BAM (8-22)

Name: BAM (8-22)
Brand: Tocris Bioscience
SKU: 1763
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1763

(1)

Citations (7)

COA / SDS

Potent MRGPRX1 agonist

Key Product Details

Description:	Potent MRGPRX1 agonist
Purity:	≥95% (HPLC)
Molecular Weight:	1971.22

View Full Technical Details for BAM (8-22)

Technical Data
Citations / Reviews (1)

Biological Activity for BAM (8-22)

BAM (8-22) is an endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC₅₀ values are 8 - 150 nM). It was first isolated from bovine adrenal medulla. Unlike BAM 22P (Cat. No. 1650), BAM (8-22) does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors. BAM (8-22) augments scratching behavior in a cholestatic pruritus mice model. BAM (8-22) attenuates bone cancer pain in mice.

Technical Data for BAM (8-22)

M. Wt	1971.22
Formula	C₉₁H₁₂₇N₂₅O₂₃S
Single Letter Sequence	VGRPEWWMDYQKRYG
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	412961-36-5
PubChem ID	16158367
InChi Key	GOEYECACIBFJGZ-NPAGUKBMSA-N
Smiles	[H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAM (8-22)

Solubility

Soluble to 1mg/ml in water

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References for BAM (8-22)

References are publications that support the biological activity of the product.

Sun Activation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. Am.J.Transl.Res. 2016 PMID: 27158400
Sanjel BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci.Rep. 2019 PMID: 31350433
Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev 2014 PMID: 24867890
Simonin and Kieffer Two faces for an opioid peptide - and more receptors for pain research. Nat.Neurosci. 2002 PMID: 11865303
Lembo Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat.Neurosci. 2002 PMID: 11850634
Chen and Ikeda Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons. J.Neurosci. 2004 PMID: 15163697