Batimastat

Name: Batimastat
Brand: Tocris Bioscience
SKU: 2961

Tocris Bioscience, part of Bio-Techne | Catalog # 2961

(1)

Citations (82)

COA / SDS

Potent, broad spectrum MMP inhibitor

Key Product Details

Chemical Name:	(2R,3S)-N⁴-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
Purity:	≥99%
Molecular Weight:	477.64 kDa

View Full Technical Details for Batimastat

Technical Data
Citations / Reviews (1)

Biological Activity for Batimastat

Batimastat is a potent, broad spectrum MMP inhibitor (IC₅₀ values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.

Technical Data for Batimastat

M. Wt	477.64 kDa
Formula	C₂₃H₃₁N₃O₄S₂
Storage	Store at -20°C
Purity	≥99%
CAS Number	130370-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Batimastat

Solubility

Soluble Soluble to 100 mM in DMSO

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References for Batimastat

References are publications that support the biological activity of the product.

Frohlich C, Klitgaard M, Noer J, Kotzsch A, Nehammer C, Kronqvist P, Berthelsen J, Blobel C, Kveiborg M, Albrechtsen R, Wewer U ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins. Biochem J, 2013;452(1):97-109. 2013 PMID: 23458101
Itagaki K, Naito T, Iwakiri R, Haga M, Miura S, Saito Y, Owaki T, Kamiya S, Iyoda T, Yajima H, Iwashita S, Ejiri S, Fukai F Eukaryotic translation elongation factor 1A induces anoikis by triggering cell detachment. J. Biol. Chem., 2012;287(19):16037-46. 2012 PMID: 22399298
MJ Carroll, A Kapur, M Felder, MS Patankar, PK Kreeger M2 macrophages induce ovarian cancer cell proliferation via a heparin binding epidermal growth factor/matrix metalloproteinase 9 intercellular feedback loop Oncotarget, 2016;7(52):86608-86620. 2016 PMID: 27888810
Sanz R, Ferraro G, Fournier A IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem, 2015;290(7):4330-42. 2015 PMID: 25538237
RL Sanz, GB Ferraro, MP Girouard, AE Fournier Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons Sci Rep, 2017;7(1):7961. 2017 PMID: 28801670
Howard, Laura, Wyatt, Sean, Nagappan, Guhan, Davies, Alun M ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism. Development, 2013;140(10):2108-17. 2013 PMID: 23633509
Brafman D, Phung C, Kumar N, Willert K Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Cell Death Differ, 2013;20(3):369-81. 2013 PMID: 23154389
Ji Y, Hwang Y, Mood K, Cho H, Lee H, Winterbottom E, Cousin H, Daar I EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1. Nat Commun, 2014;5(0):3516. 2014 PMID: 24662724
Wang, Ling, Cossette, Stephani, Rarick, Kevin R, Gershan, Jill, Dwinell, Michael, Harder, David R, Ramchandran, Ramani Astrocytes directly influence tumor cell invasion and metastasis in vivo. PLoS ONE, 2013;8(12):e80933. 2013 PMID: 24324647
Kim S, Cho Y, Kim H, Oh J, Ahn E, Ko H, Hwang B, Lee S, Cho Y, Kim Y, Stetler-Stevenson W, Seo D Antagonism of VEGF-A-induced increase in vascular permeability by an integrin alpha3beta1-Shp-1-cAMP/PKA pathway. Blood, 2012;120(24):4892-902. 2012 PMID: 23074279
Wang et al. Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res., 1994;54:4726 PMID: 8062271
Kohn and Liotta Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res., 1995;55:1856 PMID: 7728753
Davies et al. A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res., 1993;53:2087 PMID: 8347186