Bay 11-7821

Name: Bay 11-7821
Brand: Tocris Bioscience
SKU: 1744

Tocris Bioscience, part of Bio-Techne | Catalog # 1744

Citations (13)

COA / SDS

E2 ubiquitin (Ub) conjugating enzymes inhibitor

Key Product Details

Chemical Name:	(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Purity:	≥99%
Molecular Weight:	207.25 kDa

View Full Technical Details for Bay 11-7821

Technical Data
Citations

Biological Activity for Bay 11-7821

Bay 11-7821 is an E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated IκBα phosphorylation and indirectly decreases NF-κb activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines. Also inhibits activation of NLRP3 inflammasome. Binds and inhibits gasdermin D (GSDMD) pore formation. Pyroptosis inhibitor.

Technical Data for Bay 11-7821

M. Wt	207.25 kDa
Formula	C₁₀H₉NO₂S
Storage	Store at +4°C
Purity	≥99%
CAS Number	19542-67-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bay 11-7821

Solubility

Soluble Soluble to 25 mM in ethanol and to 100 mM in DMSO

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References for Bay 11-7821

References are publications that support the biological activity of the product.

Juliana et al. Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome. J.Biol.Chem., 2010;285:9792 PMID: 20093358
Mori et al. Bay 11-7082 inhibits transcription factor NF-κB and induces apoptosis of HTLV-I-infected T-cell lines and primary adult T-cell leukemia cells. Blood, 2002;100:1828 PMID: 12176906
Strickson et al. The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system. Biochem.J., 2013;451:427 PMID: 23441730
Pierce et al. Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J.Biol.Chem., 1997;272:21096 PMID: 9261113
Pandeya et al. Gasdermin D (GSDMD) as a new target for the treatment of infection. Medchemcomm, 2019;10:660 PMID: 31191857