Bay 36-7620

Name: Bay 36-7620
Brand: Tocris Bioscience
SKU: 2501

Tocris Bioscience, part of Bio-Techne | Catalog # 2501

Citations (14)

COA / SDS

mGlu1 inverse agonist

Key Product Details

Chemical Name:	(3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
Purity:	≥98%
Molecular Weight:	278.35 kDa

View Full Technical Details for Bay 36-7620

Technical Data
Citations

Biological Activity for Bay 36-7620

Bay 36-7620 is a selective mGlu₁ receptor non-competitive antagonist (IC₅₀ = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.

Technical Data for Bay 36-7620

M. Wt	278.35 kDa
Formula	C₁₉H₁₈O₂
Storage	Store at +4°C
Purity	≥98%
CAS Number	232605-26-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bay 36-7620

Solubility

Soluble Soluble to 100 mM in DMSO and to 100 mM in ethanol

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for Bay 36-7620

References are publications that support the biological activity of the product.

Kalinowska M, Chavez A, Lutzu S, Castillo P, Bukauskas F, Francesconi A Actinin-4 Governs Dendritic Spine Dynamics and Promotes Their Remodeling by Metabotropic Glutamate Receptors. J Biol Chem, 2015;290(26):15909-20. 2015 PMID: 25944910
Kumari, Ranju, Castillo, Catherin, Francesconi, Anna Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains. J Biol Chem, 2013;288(44):32004-19. 2013 PMID: 24045944
Carroll et al. BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol.Pharmacol., 2001;59:965 PMID: 11306677
De Vry et al. Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu₁ receptor antagonist BAY 36-7620. Eur.J.Pharmacol., 2001;428:203 PMID: 11675037
Gil-Sanz et al. Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice. Cereb.Cortex, 2007;18:1653 PMID: 18024992