Bay 36-7620

Name: Bay 36-7620
Brand: Tocris Bioscience
SKU: 2501

Tocris Bioscience, part of Bio-Techne | Catalog # 2501

Citations (14)

COA / SDS

mGlu1 inverse agonist

Key Product Details

Description:	mGlu₁ inverse agonist
Chemical Name:	(3aS,6aS)-Hexahydro-5-methylene-6a-(2-naphthalenylmethyl)-1H-cyclopenta[c]furan-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	278.35

View Full Technical Details for Bay 36-7620

Technical Data
Citations

Biological Activity for Bay 36-7620

Bay 36-7620 is a selective mGlu₁ receptor non-competitive antagonist (IC₅₀ = 0.16 μM) with inverse agonist activity. Impairs classical conditioning and associated synaptic plasticity in hippocampal neurons. Exhibits neuroprotective and anticonvulsive effects in vivo following systemic administration.

Licensing Information

Sold for research purposes under agreement from Bayer

Technical Data for Bay 36-7620

M. Wt	278.35
Formula	C₁₉H₁₈O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	232605-26-4
PubChem ID	9903757
InChi Key	CVIRWLJKDBYYOG-MJGOQNOKSA-N
Smiles	C=C1C[C@@]2([H])[C@@](C(OC2)=O)(CC3=CC(C=CC=C4)=C4C=C3)C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bay 36-7620

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	27.84	100
	ethanol	27.84	100

Preparing Stock Solutions for Bay 36-7620

The following data is based on the product molecular weight 278.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.59 mL	17.96 mL	35.93 mL
5 mM	0.72 mL	3.59 mL	7.19 mL
10 mM	0.36 mL	1.80 mL	3.59 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for Bay 36-7620

References are publications that support the biological activity of the product.

De Vry Neuroprotective and behavioural effects of the selective metabotropic glutamate mGlu₁ receptor antagonist BAY 36-7620. Eur.J.Pharmacol. 2001 PMID: 11675037
Gil-Sanz Involvement of the mGluR1 receptor in hippocampal synaptic plasticity and associative learning in behaving mice. Cereb.Cortex 2007 PMID: 18024992
Carroll BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity. Mol.Pharmacol. 2001 PMID: 11306677