BAY 41-2272

Name: BAY 41-2272
Brand: Tocris Bioscience
SKU: 4430

Tocris Bioscience, part of Bio-Techne | Catalog # 4430

Citations (6)

COA / SDS

Soluble guanylyl cyclase (sGC) activator

Key Product Details

Description:	Soluble guanylyl cyclase (sGC) activator
Chemical Name:	5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
Purity:	≥98% (HPLC)
Molecular Weight:	360.39

View Full Technical Details for BAY 41-2272

Technical Data
Citations

Biological Activity for BAY 41-2272

BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α₁ subunit. Inhibits platelet aggregation (IC₅₀ = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC₅₀ = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Compound Libraries for BAY 41-2272

BAY 41-2272 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BAY 41-2272

M. Wt	360.39
Formula	C₂₀H₁₇FN₆
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	256376-24-6
PubChem ID	9798973
InChi Key	ATOAHNRJAXSBOR-UHFFFAOYSA-N
Smiles	FC(C=CC=C3)=C3CN2N=C(C4=NC=C(C5CC5)C(N)=N4)C1=CC=CN=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 41-2272

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.04	100

Preparing Stock Solutions for BAY 41-2272

The following data is based on the product molecular weight 360.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.75 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for BAY 41-2272

References are publications that support the biological activity of the product.

Joshi The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth muscle growth through the cAMP-dependent protein kinase and cGMP-dependent protein kinase pathways. J.Pharmacol.Exp.Ther. 2011 PMID: 21825001
Mittendorf Discovery of Riociguat (BAY 63-2521): a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension. ChemMedChem 2009 PMID: 19263460
Stasch NO-independent regulatory site on soluble guanylate cyclase. Nature 2010 PMID: 11242081