BAY 58-2667 hydrochloride

Name: BAY 58-2667 hydrochloride
Brand: Tocris Bioscience
SKU: 6052

Tocris Bioscience, part of Bio-Techne | Catalog # 6052

Citations (2)

COA / SDS

Potent soluble guanylyl cyclase (sGC) activator

Key Product Details

Description:	Potent soluble guanylyl cyclase (sGC) activator
Alternative Names:	Cinaciguat hydrochloride
Chemical Name:	4-[[(4-Carboxybutyl)[2-[2-[[4-(2-phenylethyl)phenyl]methoxy]phenyl]ethyl]amino]methyl]benzoic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	602.16

View Full Technical Details for BAY 58-2667 hydrochloride

Technical Data
Citations

Biological Activity for BAY 58-2667 hydrochloride

BAY 58-2667 hydrochloride is a potent soluble guanylyl cyclase (sGC) activator (EC₅₀ = 6.4 nM). Binds heme-free sGC. Exhibits antihypertensive effects in vivo.

Technical Data for BAY 58-2667 hydrochloride

M. Wt	602.16
Formula	C₃₆H₃₉NO₅.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	646995-35-9
PubChem ID	10031513
InChi Key	LLHMBJOVHATVSP-UHFFFAOYSA-N
Smiles	OC(CCCCN(CC1=CC=C(C(O)=O)C=C1)CCC2=C(C=CC=C2)OCC3=CC=C(C=C3)CCC4=CC=CC=C4)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 58-2667 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	60.22	100

Preparing Stock Solutions for BAY 58-2667 hydrochloride

The following data is based on the product molecular weight 602.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.66 mL	8.30 mL	16.61 mL
5 mM	0.33 mL	1.66 mL	3.32 mL
10 mM	0.17 mL	0.83 mL	1.66 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for BAY 58-2667 hydrochloride

References are publications that support the biological activity of the product.

Stasch Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J.Clin.Invest. 2006 PMID: 16955146
Roy Probing the presence of the ligand-binding haem in cellular nitric oxide receptors. Br.J.Pharmacol. 2008 PMID: 18204474
Stasch NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle. Br.J.Pharmacol. 2002 PMID: 12086987