BAY 6035

Name: BAY 6035
Brand: Tocris Bioscience
SKU: 6561

Tocris Bioscience, part of Bio-Techne | Catalog # 6561

COA / SDS

Potent and selective SMYD3 inhibitor

Key Product Details

Description:	Potent and selective SMYD3 inhibitor
Chemical Name:	(2S)-1-(3-Azabicyclo[3.1.0]hex-3-ylcarbonyl)-N-(2-cyclopropylethyl)-2,3,4,5-tetrahydro-2-methyl-4-oxo-1H-1,5-benzodiazepine-7-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	396.48

View Full Technical Details for BAY 6035

Technical Data
Citations

Biological Activity for BAY 6035

BAY 6035 is a potent SMYD3 inhibitor (IC₅₀ = 70 nM for inhibition of MEKK2 methylation in cells). Exhibits >100-fold selectivity for SMYD3 over other histone methyltransferases.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BAY-6035 probe summary on the SGC website.

Compound Libraries for BAY 6035

BAY 6035 is also offered as part of the Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

Technical Data for BAY 6035

M. Wt	396.48
Formula	C₂₂H₂₈N₄O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2247890-13-5
PubChem ID	137499231
InChi Key	CKFRXCBNKKOFGO-IGEOTXOUSA-N
Smiles	O=C(NCCC1CC1)C2=CC=C3N([C@H](CC(NC3=C2)=O)C)C(N4CC5CC5C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BAY 6035

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	39.65	100
	ethanol	39.65	100

Preparing Stock Solutions for BAY 6035

The following data is based on the product molecular weight 396.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.50 mL	2.52 mL	5.04 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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Product Documents for BAY 6035

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.