BCTC

Name: BCTC
Brand: Tocris Bioscience
SKU: 3875

Tocris Bioscience, part of Bio-Techne | Catalog # 3875

Citations (34)

COA / SDS

TRPV1 antagonist

Key Product Details

Description:	TRPV1 antagonist
Chemical Name:	4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	372.89

View Full Technical Details for BCTC

Technical Data
Citations

Biological Activity for BCTC

BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC₅₀ values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.

Compound Libraries for BCTC

BCTC is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BCTC

M. Wt	372.89
Formula	C₂₀H₂₅ClN₄O
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	393514-24-4
PubChem ID	9929425
InChi Key	ROGUAPYLUCHQGK-UHFFFAOYSA-N
Smiles	ClC1=CC=CN=C1N2CCN(C(NC3=CC=C(C(C)(C)C)C=C3)=O)CC2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BCTC

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.29	100
	ethanol	14.92	40

Preparing Stock Solutions for BCTC

The following data is based on the product molecular weight 372.89.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.41 mL	26.82 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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References for BCTC

References are publications that support the biological activity of the product.

Valenzano N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. In vitro characterization and pharmacokinetic proper J.Pharmacol.Exp.Ther. 2003 PMID: 12721338
Pomonis N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. In vivo characterization in rat models of inflamma J.Pharmacol.Exp.Ther. 2003 PMID: 12721336