Bendamustine hydrochloride

Name: Bendamustine hydrochloride
Brand: Tocris Bioscience
SKU: 3681
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3681

(1)

Citations (2)

COA / SDS

Cytostatic agent; exhibits DNA alkylating and purine analog properties

Key Product Details

Description:	Cytostatic agent; exhibits DNA alkylating and purine analog properties
Chemical Name:	5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	394.72

View Full Technical Details for Bendamustine hydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Bendamustine hydrochloride

Bendamustine hydrochloride is a cytostatic agent that displays activity in non-Hodgkin's lymphomas. Exhibits bifunctionality; combines DNA alkylating properties with those of purine analogs.

Technical Data for Bendamustine hydrochloride

M. Wt	394.72
Formula	C₁₆H₂₁Cl₂N₃O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	3543-75-7
PubChem ID	77082
InChi Key	ZHSKUOZOLHMKEA-UHFFFAOYSA-N
Smiles	CN2C1=CC=C(N(CCCl)CCCl)C=C1N=C2CCCC(O)=O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bendamustine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	9.87	25
	DMSO	39.47	100

Preparing Stock Solutions for Bendamustine hydrochloride

The following data is based on the product molecular weight 394.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.53 mL	12.67 mL	25.33 mL
5 mM	0.51 mL	2.53 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.53 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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Reconstitution Calculator

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References for Bendamustine hydrochloride

References are publications that support the biological activity of the product.

Keating Bendamustine. Nat.Rev.Drug Discov. 2008 PMID: 18511926
Masiello and Tulpule Bendamustine therapy in chronic lymphocytic leukemia. Expert Opin.Pharmacother. 2009 PMID: 19527193
Schwanen In vitro evaluation of bendamu. induced apoptosis in B-chronic lymphocytic leukemia. Leukemia. 2002 PMID: 12357363