Benzamil

Name: Benzamil
Brand: Tocris Bioscience
SKU: 3380

Tocris Bioscience, part of Bio-Techne | Catalog # 3380

Citations (10)

COA / SDS

NCX inhibitor, Deg/ENaC channel blocker; amiloride (Cat. No. 0890) derivative

Key Product Details

Chemical Name:	N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
Purity:	≥98%

View Full Technical Details for Benzamil

Technical Data
Citations

Biological Activity for Benzamil

Benzamil is a Na⁺/Ca²⁺ exhanger (NCX) inhibitor (IC₅₀ ~ 100 nM); TRPP3 channel blocker (IC₅₀ = 1.1 μM for inhibition of Ca²⁺-activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).

Technical Data for Benzamil

Formula	C₁₃H₁₄ClN₇O.HCl
Storage	Store at +4°C
Purity	≥98%
CAS Number	161804-20-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Benzamil

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in water

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References for Benzamil

References are publications that support the biological activity of the product.

Fischer et al. Characterization of a Na⁺-Ca²⁺ exchanger in podocytes. Nephrol.Dial.Transplant., 2002;17:1742 PMID: 12270979
Page et al. Acid sensing ion channels 2 and 3 are required for inhibition of visceral nociceptors by benzamil. Pain, 2007;133:150 PMID: 17467171
Dai et al. Inhibition of TRPP3 channel by amil. and analogs. Mol.Pharmacol., 2007;72:1576 PMID: 17804601

Benzamil

Tocris Bioscience, part of Bio-Techne | Catalog # 3380

Key Product Details

Biological Activity for Benzamil

Technical Data for Benzamil

Solubility for Benzamil

Dilution Calculator

Reconstitution Calculator

References for Benzamil

Product Documents for Benzamil

COA

Certificate of Analysis

SDS

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