Betulinic acid

Name: Betulinic acid
Brand: Tocris Bioscience
SKU: 3906

Tocris Bioscience, part of Bio-Techne | Catalog # 3906

Citations (15)

COA / SDS

Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist

Key Product Details

Description:	Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
Chemical Name:	(+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid
Molecular Weight:	456.7

View Full Technical Details for Betulinic acid

Technical Data
Citations

Biological Activity for Betulinic acid

Betulinic acid is a natural triterpenoid that displays anti-HIV and antitumor activity. Induces the production of reactive oxygen species (ROS) and activates NF-κB. Also a GPBA receptor partial agonist (EC₅₀ = 1.04 μM, efficacy 83%). Betulinic acid suppresses areobic glycolysis by regulating the Cav-1/NF-κB/c-Myc pathway in and inhibits growth in breast cancer cells.

Technical Data for Betulinic acid

M. Wt	456.7
Formula	C₃₀H₄₈O₃
Storage	Store at +4°C
CAS Number	472-15-1
PubChem ID	64971
InChi Key	QGJZLNKBHJESQX-FZFNOLFKSA-N
Smiles	O[C@H]1CC[C@@]2(C)[C@](CC[C@]3(C)[C@@]([H])2CC[C@@]4([H])[C@](C)3CC[C@]5([C@](O)=O)[C@@]([H])4[C@H]([C@@](C)=C)CC5)([H])C(C)1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Betulinic acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.84	50

Preparing Stock Solutions for Betulinic acid

The following data is based on the product molecular weight 456.7.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.38 mL	21.90 mL	43.79 mL
2.5 mM	0.88 mL	4.38 mL	8.76 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
25 mM	0.09 mL	0.44 mL	0.88 mL

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References for Betulinic acid

References are publications that support the biological activity of the product.

Jiao Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-?B/c-Myc pathway. Biochem.Pharmacol. 2019 PMID: 30684465
Fulda Betulinic acid for cancer treatment and prevention. Int.J.Mol.Sci. 2008 PMID: 19325847
Genet Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J.Med.Chem. 2010 PMID: 19911773
Kashiwada Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents. J.Med.Chem. 1996 PMID: 8676334