BGC 20-761

Name: BGC 20-761
Brand: Tocris Bioscience
SKU: 3326

Tocris Bioscience, part of Bio-Techne | Catalog # 3326

Citations (1)

COA / SDS

High affinity 5-HT6 antagonist

Key Product Details

Description:	High affinity 5-HT₆ antagonist
Chemical Name:	5-Methoxy-N,N-dimethyl-2-phenyl-1H-indole-3-ethanamine
Purity:	≥98% (HPLC)
Molecular Weight:	294.39

View Full Technical Details for BGC 20-761

Technical Data
Citations

Biological Activity for BGC 20-761

BGC 20-761 is a selective, high affinity 5-HT₆ antagonist (K_i = 20 nM). Reverses the amnesic effects of scopolamine (Cat. No. 1414) and enhances memory consolidation in a rat model.

Technical Data for BGC 20-761

M. Wt	294.39
Formula	C₁₉H₂₂N₂O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	17375-63-2
PubChem ID	6918515
InChi Key	VSGPGYWZVPDDSK-UHFFFAOYSA-N
Smiles	CN(CCC2=C(C3=CC=CC=C3)NC1=CC=C(OC)C=C12)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BGC 20-761

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	29.44	100
	ethanol	14.72	50

Preparing Stock Solutions for BGC 20-761

The following data is based on the product molecular weight 294.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	16.98 mL	33.97 mL
5 mM	0.68 mL	3.40 mL	6.79 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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Reconstitution Calculator

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References for BGC 20-761

References are publications that support the biological activity of the product.

Mitchell BGC20-761, a novel tryptamine analog, enhances memory consolidation and reverses scopolamine-induced memory deficit in social and visuospatial memory tasks through a 5-HT6 receptor-mediated mechanism. Neuropharmacology 2006 PMID: 16298400
Glennon 2-substituted tryptamines: agents with selectivity for 5-HT₆ serotonin receptors. J.Med.Chem. 2000 PMID: 10715164