BI-6901

Name: BI-6901
Brand: Tocris Bioscience
SKU: 6141

Tocris Bioscience, part of Bio-Techne | Catalog # 6141

COA / SDS

Potent and selective CCR10 antagonist

Key Product Details

Description:	Potent and selective CCR10 antagonist
Chemical Name:	N-[(1R)-3-(2-Cyano-1H-pyrrol-1-yl)-1-[(4-methyl-1-piperidinyl)carbonyl]propyl]-1H-indole-4-sulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	453.56

View Full Technical Details for BI-6901

Technical Data
Citations

Biological Activity for BI-6901

BI-6901 is a potent and selective CCR10 antagonist (IC₅₀ = 1 - 25 nM). BI-6901 inhibits CCL27-dependent chemotaxis of Ba/F3 cells (IC₅₀ = 1 nM) and reduces inflammation in a DNFB-stimulated animal model of contact hypersensitivity.

Technical Data for BI-6901

M. Wt	453.56
Formula	C₂₃H₂₇N₅O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2040401-92-9
PubChem ID	131801164
InChi Key	BRJXJOWXAFLRTE-OAQYLSRUSA-N
Smiles	CC1CCN(C([C@H](NS(=O)(C2=C3C=CNC3=CC=C2)=O)CCN4C=CC=C4C#N)=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BI-6901

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.36	100
	ethanol	45.36	100

Preparing Stock Solutions for BI-6901

The following data is based on the product molecular weight 453.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	11.02 mL	22.05 mL
5 mM	0.44 mL	2.20 mL	4.41 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for BI-6901

References are publications that support the biological activity of the product.

Abeywardane N-Arylsulfonyl-a-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity. Bioorg.Med.Chem.Lett. 2016 PMID: 27692854