BI 9564

Name: BI 9564
Brand: Tocris Bioscience
SKU: 5590

Tocris Bioscience, part of Bio-Techne | Catalog # 5590

Citations (4)

COA / SDS

Potent and selective BRD9 and BRD7 inhibitor; orally active

Key Product Details

Description:	Potent and selective BRD9 and BRD7 inhibitor; orally active
Chemical Name:	4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	353.41

View Full Technical Details for BI 9564

Technical Data
Citations

Biological Activity for BI 9564

BI 9564 is a potent and selective BRD9 and BRD7 inhibitor (K_d values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo. Cell permeable and orally active.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the BI 9564 probe summary on the SGC website.

Compound Libraries for BI 9564

BI 9564 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. Find out more about compound libraries available from Tocris.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BI-9564 is reviewed on the chemical probes website.

Technical Data for BI 9564

M. Wt	353.41
Formula	C₂₀H₂₃N₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1883429-22-8
PubChem ID	117072549
InChi Key	BJFSUDWKXGMUKA-UHFFFAOYSA-N
Smiles	O=C(N(C)C=C1C2=CC(OC)=C(CN(C)C)C=C2OC)C3=C1C=CN=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BI 9564

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	7.07	20
	1eq. HCl	3.53	10 with gentle warming

Preparing Stock Solutions for BI 9564

The following data is based on the product molecular weight 353.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	14.15 mL	70.74 mL	141.48 mL
1 mM	2.83 mL	14.15 mL	28.30 mL
2 mM	1.41 mL	7.07 mL	14.15 mL
10 mM	0.28 mL	1.41 mL	2.83 mL

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References for BI 9564

References are publications that support the biological activity of the product.

Karim and Schönbrunn An Advanced Tool To Interrogate BRD9. J.Med.Chem. 2016 PMID: 27120693
Martin Structure-based design of an in vivo active selective BRD9 inhibitor J.Med.Chem. 2016 PMID: 26914985