BIBN 4096

Name: BIBN 4096
Brand: Tocris Bioscience
SKU: 4561

Tocris Bioscience, part of Bio-Techne | Catalog # 4561

Citations (55)

COA / SDS

Potent and selective CGRP antagonist

Key Product Details

Description:	Potent and selective CGRP antagonist
Alternative Names:	Olcegepant
Chemical Name:	1-[3,5-Dibromo-N-[[4-(1,4-dihydro-2-oxo-3(2H)-quinazolinyl)-1-piperidinyl]carbonyl]-D-tyrosyl-L-lysyl]-4-(4-pyridinyl)-piperazine
Purity:	≥95% (HPLC)
Molecular Weight:	869.65

View Full Technical Details for BIBN 4096

Technical Data
Citations

Biological Activity for BIBN 4096

BIBN 4096 is a potent and selective CGRP receptor antagonist (IC₅₀ values are 0.03 and 6.4 nM for human and rat CGRP receptors respectively). Displays high affinity for human CGRP receptors (K_i = 14.4 pM); exhibits no significant affinity for 75 other receptors. BIBN 4096 improves pain symptoms in a mouse migraine model.

Technical Data for BIBN 4096

M. Wt	869.65
Formula	C₃₈H₄₇Br₂N₉O₅
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	204697-65-4
PubChem ID	6918509
InChi Key	ITIXDWVDFFXNEG-JHOUSYSJSA-N
Smiles	O=C(N[C@H](CC4=CC(Br)=C(O)C(Br)=C4)C(N[C@@H](CCCCN)C(N5CCN(C6=CC=NC=C6)CC5)=O)=O)N(CC3)CCC3N2CC1=CC=CC=C1NC2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIBN 4096

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	43.48	50
	2eq.HCl	43.48	50

Preparing Stock Solutions for BIBN 4096

The following data is based on the product molecular weight 869.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.30 mL	11.50 mL	23.00 mL
2.5 mM	0.46 mL	2.30 mL	4.60 mL
5 mM	0.23 mL	1.15 mL	2.30 mL
25 mM	0.05 mL	0.23 mL	0.46 mL

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References for BIBN 4096

References are publications that support the biological activity of the product.

Rudolf Development of human calcitonin gene-related peptide (CGRP) receptor antagonists. 1. Potent and selective small molecule CGRP antagonists. 1-[N2-[3,5-Dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1- piperidinyl J.Med.Chem. 2005 PMID: 16161996
Prado TREK channel activation suppresses migraine pain phenotype. iScience 2021 PMID: 34458705
Doods Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br.J.Pharmacol. 2000 PMID: 10711339