BIBR 1532

Name: BIBR 1532
Brand: Tocris Bioscience
SKU: 2981
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2981

(1)

Citations (15)

COA / SDS

Selective telomerase inhibitor

Key Product Details

Description:	Selective telomerase inhibitor
Chemical Name:	2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	331.36

View Full Technical Details for BIBR 1532

Technical Data
Citations / Reviews (1)

Biological Activity for BIBR 1532

BIBR 1532 is a selective telomerase inhibitor (IC₅₀ values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

Compound Libraries for BIBR 1532

BIBR 1532 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BIBR 1532

M. Wt	331.36
Formula	C₂₁H₁₇NO₃
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	321674-73-1
PubChem ID	9927531
InChi Key	PGFQXGLPJUCTOI-WYMLVPIESA-N
Smiles	C/C(C2=CC1=CC=CC=C1C=C2)=C\C(NC3=C(C(O)=O)C=CC=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BIBR 1532

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.14	100
	ethanol	8.28	25

Preparing Stock Solutions for BIBR 1532

The following data is based on the product molecular weight 331.36.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.09 mL	30.18 mL
5 mM	0.60 mL	3.02 mL	6.04 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for BIBR 1532

References are publications that support the biological activity of the product.

Phatak and Burger Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol. 2007 PMID: 17603541
Rankin Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs 2008 PMID: 18454043
Damm A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J. 2001 PMID: 11742973