BINA

Name: BINA
Brand: Tocris Bioscience
SKU: 4048

Tocris Bioscience, part of Bio-Techne | Catalog # 4048

Citations (11)

COA / SDS

Selective positive allosteric modulator of mGlu2 receptors

Key Product Details

Description:	Selective positive allosteric modulator of mGlu₂ receptors
Alternative Names:	Biphenyl-indanone A
Chemical Name:	3'-[[(2-Cyclopentyl-2,3-dihydro-6,7-dimethyl-1-oxo-1H-inden-5-yl)oxy]methyl]-[1,1'-biphenyl]-4-carboxylic acid
Purity:	≥98% (HPLC)
Molecular Weight:	454.56

View Full Technical Details for BINA

Technical Data
Citations

Biological Activity for BINA

BINA is a selective positive allosteric modulator of mGlu₂ (EC₅₀ = 33.2 nM in CHO cells expressing human mGlu₂). Displays no effect on glutamate-induced activation of other mGlu receptor subtypes. Exhibits antipsychotic and anxiolytic properties in mice.

Compound Libraries for BINA

BINA is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for BINA

M. Wt	454.56
Formula	C₃₀H₃₀O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	866823-73-6
PubChem ID	9868580
InChi Key	KMKBEESNZAPKMP-UHFFFAOYSA-N
Smiles	CC1=C(C)C(C(C(C5CCCC5)C4)=O)=C4C=C1OCC2=CC(C3=CC=C(C(O)=O)C=C3)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BINA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	45.46	100

Preparing Stock Solutions for BINA

The following data is based on the product molecular weight 454.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.20 mL	11.00 mL	22.00 mL
5 mM	0.44 mL	2.20 mL	4.40 mL
10 mM	0.22 mL	1.10 mL	2.20 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for BINA

References are publications that support the biological activity of the product.

Galici Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J.Pharmacol.Exp.Ther. 2006 PMID: 16608916
Benneyworth A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol.Pharmacol. 2007 PMID: 17526600
Bonnefous Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor. Bioorg.Med.Chem.Lett. 2005 PMID: 16046122