BMS 303141

Name: BMS 303141
Brand: Tocris Bioscience
SKU: 4609

Tocris Bioscience, part of Bio-Techne | Catalog # 4609

Citations (22)

COA / SDS

ATP citrate lyase inhibitor; orally bioavailable

Key Product Details

Description:	ATP citrate lyase inhibitor; orally bioavailable
Chemical Name:	3,5-Dichloro-2-hydroxy-N-(4-methoxy[1,1'-biphenyl]-3-yl)-benzenesulfonamide
Purity:	≥98% (HPLC)
Molecular Weight:	424.3

View Full Technical Details for BMS 303141

Technical Data
Citations

Biological Activity for BMS 303141

BMS 303141 is an ATP citrate lyase (ACL) inhibitor (IC₅₀ = 0.13 μM for human recombinant ACL); blocks lipid synthesis (IC₅₀ = 8 μM in HepG2 cells). Displays no cytotoxicity up to a concentration of 50 μM. Lowers plasma glucose and triglycerides in a mouse model of hyperlipidemia; reduces cell proliferation in HepG2 and Huh-7 cell lines and in PD-1 deficient lymphomas. Orally bioavailable.

Technical Data for BMS 303141

M. Wt	424.3
Formula	C₁₉H₁₅Cl₂NO₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	943962-47-8
PubChem ID	90488956
InChi Key	LIZVMVYXZWADCK-UHFFFAOYSA-N
Smiles	ClC1=CC(Cl)=C(O)C=C1S(NC2=C(C3=CC=CC=C3)C=CC(OC)=C2)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 303141

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	4.24	10
	ethanol	21.21	50

Preparing Stock Solutions for BMS 303141

The following data is based on the product molecular weight 424.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.71 mL	23.57 mL	47.14 mL
2.5 mM	0.94 mL	4.71 mL	9.43 mL
5 mM	0.47 mL	2.36 mL	4.71 mL
25 mM	0.09 mL	0.47 mL	0.94 mL

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References for BMS 303141

References are publications that support the biological activity of the product.

Ma A novel direct homogeneous assay for ATP citrate lyase. J.Lipid Res. 2009 PMID: 19286649
Wartewig PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma. Nat.Cancer 2023 PMID: 37723306
Li 2-hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors. Bioorg.Med.Chem.Lett. 2007 PMID: 17383874