BMS 564929

Name: BMS 564929
Brand: Tocris Bioscience
SKU: 5274

Tocris Bioscience, part of Bio-Techne | Catalog # 5274

Citations (4)

COA / SDS

Highly potent and muscle-selective androgen receptor (AR) agonist

Key Product Details

Description:	Highly potent and muscle-selective androgen receptor (AR) agonist
Chemical Name:	2-Chloro-3-methyl-4-[(7R,7aS)-tetrahydro-7-hydroxy-1,3-dioxo-1H-pyrrolo[1,2-c]imidazol-2(3H)-yl]benzonitrile
Purity:	≥98% (HPLC)
Molecular Weight:	305.72

View Full Technical Details for BMS 564929

Technical Data
Citations

Biological Activity for BMS 564929

BMS 564929 is a highly potent and selective androgen receptor (AR) agonist (EC₅₀ = 0.44 nM). Exhibits selectivity for ARs over estrogen, glucocorticoid and mineralocorticoid receptors and no significant binding to steroid hormone binding globulin or aromatase. Also exhibits selectivity for muscle over prostate ARs. Active in vivo and orally bioavailable.

Technical Data for BMS 564929

M. Wt	305.72
Formula	C₁₄H₁₂ClN₃O₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	627530-84-1
PubChem ID	49823417
InChi Key	KEJORAMIZFOODM-UHFFFAOYSA-N
Smiles	[H][C@@]12[C@H](O)CCN1C(=O)N(C2=O)C1=CC=C(C#N)C(Cl)=C1C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 564929

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	30.57	100

Preparing Stock Solutions for BMS 564929

The following data is based on the product molecular weight 305.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.27 mL	16.35 mL	32.71 mL
5 mM	0.65 mL	3.27 mL	6.54 mL
10 mM	0.33 mL	1.64 mL	3.27 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for BMS 564929

References are publications that support the biological activity of the product.

Ostrowski Pharmacological and X-ray structural characterization of a novel selective androgen receptor modulator: potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats. Endocrinology