BMS 961

Name: BMS 961
Brand: Tocris Bioscience
SKU: 3410

Tocris Bioscience, part of Bio-Techne | Catalog # 3410

Citations (26)

COA / SDS

Selective RARγ agonist

Key Product Details

Chemical Name:	3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid
Purity:	≥97%
Molecular Weight:	399.46 kDa

View Full Technical Details for BMS 961

Technical Data
Citations

Biological Activity for BMS 961

BMS 961 is a selective RARγ agonist (EC₅₀ values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.

Technical Data for BMS 961

M. Wt	399.46 kDa
Formula	C₂₃H₂₆FNO₄
Storage	Store at +4°C
Purity	≥97%
CAS Number	185629-22-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMS 961

Solubility

Soluble Soluble to 100 mM in DMSO

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References for BMS 961

References are publications that support the biological activity of the product.

Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity. Biochem Biophys Res Commun, 2014;454(4):537-542. 2014 PMID: 25450689
Taneja et al. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts. Proc.Natl.Acad.Sci.USA, 1996;93:6197
Abu-Abed et al. Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α. J.Biol.Chem., 1998;273:2409 PMID: 9442090
Klaholz et al. Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ. Proc.Natl.Acad.Sci., 2000;97:6322