BMX-IN-1

Name: BMX-IN-1
Brand: Tocris Bioscience
SKU: 5123

Tocris Bioscience, part of Bio-Techne | Catalog # 5123

Citations (1)

COA / SDS

Potent and irreversible BMX inhibitor

Key Product Details

Description:	Potent and irreversible BMX inhibitor
Chemical Name:	N-[2-Methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1,6-naphthyridin-1(2H)-yl]phenyl]-2-propenamide
Purity:	≥98% (HPLC)
Molecular Weight:	524.59

View Full Technical Details for BMX-IN-1

Technical Data
Citations

Biological Activity for BMX-IN-1

BMX-IN-1 is a potent and irreversible BMX inhibitor (IC₅₀ = 25 nM). Covalently modifies Cysteine 496. Demonstrates selectivity over other Tec family members with identically positioned reactive cysteine residue in vitro. Reduces cell number and induces apoptosis in prostate cancer cell lines. Also inhibits proliferation and reduces viability in HeLa and SiHa cell lines.

Licensing Information

Sold under license from Dana-Farber Cancer Institute.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of BMX-IN-1 is reviewed on the chemical probes website.

Technical Data for BMX-IN-1

M. Wt	524.59
Formula	C₂₉H₂₄N₄O₄S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1431525-23-3
PubChem ID	71576693
InChi Key	SFMJNHNUOVADRW-UHFFFAOYSA-N
Smiles	CC(C=C5)=C(NC(C=C)=O)C=C5N(C2=C(C=C3)C=NC1=CC=C(C4=CC=C(NS(=O)(C)=O)C=C4)C=C12)C3=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BMX-IN-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	0.52	1 with gentle warming

Preparing Stock Solutions for BMX-IN-1

The following data is based on the product molecular weight 524.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.01 mM	190.63 mL	953.13 mL	1,906.25 mL
0.05 mM	38.13 mL	190.63 mL	381.25 mL
0.1 mM	19.06 mL	95.31 mL	190.63 mL
0.5 mM	3.81 mL	19.06 mL	38.13 mL

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References for BMX-IN-1

References are publications that support the biological activity of the product.

Li BMX/Etk promotes cell proliferation and tumorigenicity of cervical cancer cells through PI3K/AKT/mTOR and STAT3 pathways. Oncotarget. 2017 PMID: 28514765
Liu Discovery of a selective irreversible BMX inhibitor for prostate cancer. ACS Chem.Biol. 2013 PMID: 23594111