Boc-MLF

Tocris Bioscience, part of Bio-Techne | Catalog # 3730

COA / SDS

FPR1 antagonist

Key Product Details

Description:	FPR1 antagonist
Purity:	≥95% (HPLC)
Molecular Weight:	509.66

View Full Technical Details for Boc-MLF

Technical Data
Citations

Biological Activity for Boc-MLF

Boc-MLF is an antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC₅₀ of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.

Technical Data for Boc-MLF

M. Wt	509.66
Formula	C₂₅H₃₉N₃O₆S
Single Letter Sequence	Boc-MLF
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	67247-12-5
PubChem ID	14655143
InChi Key	GYBXWOPENJVQKE-UFYCRDLUSA-N
Smiles	O=C([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)CCSC)=O)CC(C)C)N[C@H]([C@@](O)=O)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Boc-MLF

Solubility

Soluble to 2mg/ml in DMSO

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References for Boc-MLF

References are publications that support the biological activity of the product.

Stenfeldt Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor. Inflammation 2007 PMID: 17687636
Karlsson Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J.Leuko.Biol.
Boxio The immunostimulatory peptide WKYMVm-NH₂ activates bone marrow mouse neutrophils via multiple signal transduction pathways. Scand.J.Immunol. 2005 PMID: 16101820