BPTES

Name: BPTES
Brand: Tocris Bioscience
SKU: 5301
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5301

(1)

Citations (13)

COA / SDS

Selective allosteric glutaminase (GLS1) inhibitor

Key Product Details

Description:	Selective allosteric glutaminase (GLS1) inhibitor
Chemical Name:	N,N'-[Thiobis(2,1-ethanediyl-1,3,4-thiadiazole-5,2-diyl)]bisbenzeneacetamide
Purity:	≥95% (HPLC)
Molecular Weight:	524.68

View Full Technical Details for BPTES

Technical Data
Citations / Reviews (1)

Biological Activity for BPTES

BPTES is an allosteric glutaminase (GLS1) inhibitor (IC₅₀ = 3.3 μM). Selective for GLS1 over GLS2 and γ-glutamyl transpeptidase. Induces cell death of P493 human lymphoma B cells in vitro and reduces tumor volume of P493 cell xenografts in mice.

Technical Data for BPTES

M. Wt	524.68
Formula	C₂₄H₂₄N₆O₂S₃
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	314045-39-1
PubChem ID	3372016
InChi Key	MDJIPXYRSZHCFS-UHFFFAOYSA-N
Smiles	O=C(NC2=NN=C(CCSCCC4=NN=C(S4)NC(CC3=CC=CC=C3)=O)S2)CC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BPTES

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.49	20

Preparing Stock Solutions for BPTES

The following data is based on the product molecular weight 524.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.53 mL	47.65 mL	95.30 mL
1 mM	1.91 mL	9.53 mL	19.06 mL
2 mM	0.95 mL	4.76 mL	9.53 mL
10 mM	0.19 mL	0.95 mL	1.91 mL

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References for BPTES

References are publications that support the biological activity of the product.

Shukla Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors. J.Med.Chem. 2012 PMID: 23151085
DeLaBarre Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry 2011 PMID: 22049910
Le Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells. Cell.Metab. 2012 PMID: 22225880