BQ 788 sodium salt

Name: BQ 788 sodium salt
Brand: Tocris Bioscience
SKU: 1500
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1500

Citations (45)

COA / SDS

Selective ETB antagonist

Key Product Details

Description:	Selective ET_B antagonist
Chemical Name:	N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucine sodium salt
Purity:	≥95% (HPLC)
Molecular Weight:	663.79

View Full Technical Details for BQ 788 sodium salt

Technical Data
Citations

Biological Activity for BQ 788 sodium salt

BQ 788 sodium salt is a potent, selective ET_B receptor antagonist (IC₅₀ = 1.2 nM for inhibition of ET-1 binding to human Girardi heart cells).

Technical Data for BQ 788 sodium salt

M. Wt	663.79
Formula	C₃₄H₅₀N₅NaO₇
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	156161-89-6
PubChem ID	16759603
InChi Key	QCVIFBRTTLMEOV-FUKQNADPSA-M
Smiles	[Na+].CCCC[C@@H](NC(=O)[C@@H](CC1=CN(C(=O)OC)C2=C1C=CC=C2)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@@H](C)CCC[C@H]1C)C([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BQ 788 sodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	3.32	5

Preparing Stock Solutions for BQ 788 sodium salt

The following data is based on the product molecular weight 663.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	30.13 mL	150.65 mL	301.30 mL
0.25 mM	6.03 mL	30.13 mL	60.26 mL
0.5 mM	3.01 mL	15.07 mL	30.13 mL
2.5 mM	0.60 mL	3.01 mL	6.03 mL

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References for BQ 788 sodium salt

References are publications that support the biological activity of the product.

Ishikawa Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc.Natl.Acad.Sci.U.S.A. 1994 PMID: 8197152
Okada and Nishikibe BQ-788, a selective endothelin ET_B receptor antagonist. Cardiovasc.Drug Rev. 2002 PMID: 12070534
Davenport International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature. Pharmacol.Rev. 2002 PMID: 12037137