Bretazenil

Name: Bretazenil
Brand: Tocris Bioscience
SKU: 3568

Tocris Bioscience, part of Bio-Techne | Catalog # 3568

Citations (1)

COA / SDS

Benzodiazepine partial agonist

Key Product Details

Description:	Benzodiazepine partial agonist
Alternative Names:	Ro 16-6028
Chemical Name:	(13aS)-8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid 1,1-dimethylethyl ester
Purity:	≥98% (HPLC)
Molecular Weight:	418.28

View Full Technical Details for Bretazenil

Technical Data
Citations

Biological Activity for Bretazenil

Bretazenil is a partial agonist at the GABA_A benzodiazepine site (EC₅₀ = 10 nM at α1β1γ2 receptors). Displays anticonvulsive activity in vivo.

Technical Data for Bretazenil

M. Wt	418.28
Formula	C₁₉H₂₀BrN₃O₃
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	84379-13-5
PubChem ID	107926
InChi Key	LWUDDYHYYNNIQI-ZDUSSCGKSA-N
Smiles	O=C(N4[C@]([H])3CCC4)C1=C(Br)C=CC=C1N2C3=C(C(OC(C)(C)C)=O)N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bretazenil

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	41.83	100
	ethanol	41.83	100

Preparing Stock Solutions for Bretazenil

The following data is based on the product molecular weight 418.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.95 mL	23.91 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.20 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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Reconstitution Calculator

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References for Bretazenil

References are publications that support the biological activity of the product.

Munro Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with D.pam, zolpidem, bretazenil, and gaboxadol in rat models of i J.Pharmacol.Exp.Ther. 2008 PMID: 18791060
Puia Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor. Proc.Natl.Acad.Sci. USA Neurobiology
Rundfeldt Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of D.pam, bretazenil and abecarnil. J.Pharmacol.Exp.Ther. 1995 PMID: 7473156