BRL 50481

Name: BRL 50481
Brand: Tocris Bioscience
SKU: 2237

Tocris Bioscience, part of Bio-Techne | Catalog # 2237

Citations (12)

COA / SDS

Selective PDE7 inhibitor

Key Product Details

Chemical Name:	N,N,2-Trimethyl-5-nitro-benzenesulfonamide
Purity:	≥99%
Molecular Weight:	244.26 kDa

View Full Technical Details for BRL 50481

Technical Data
Citations

Biological Activity for BRL 50481

BRL 50481 is a selective, substrate-competitive inhibitor of phosphodiesterase (PDE) 7 (K_i = 180 nM). Displays > 200-fold selectivity over PDE1B, PDE1C, PDE2, PDE3, PDE4A4 and PDE5.

Technical Data for BRL 50481

M. Wt	244.26 kDa
Formula	C₉H₁₂N₂O₄S
Storage	Store at +4°C
Purity	≥99%
CAS Number	433695-36-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BRL 50481

Solubility

Soluble Soluble to 100 mM in ethanol and to 100 mM in DMSO

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References for BRL 50481

References are publications that support the biological activity of the product.

Zhai K, Hubert F, Nicolas V, Ji G, Fischmeister R, Leblais V beta-Adrenergic cAMP signals are predominantly regulated by phosphodiesterase type 4 in cultured adult rat aortic smooth muscle cells. PLoS ONE, 2012;7(10):e47826. 2012 PMID: 23094097
Smith et al. Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a selective inhibitor of phosphodiesterase 7: in vitro studies in human monocytes, lung macrophages, and CD8⁺ T-lymphocytes. Mol.Pharmacol., 2004;66:1679 PMID: 15371556