Bupropion hydrochloride

Name: Bupropion hydrochloride
Brand: Tocris Bioscience
SKU: 2831

Tocris Bioscience, part of Bio-Techne | Catalog # 2831

Citations (5)

COA / SDS

Non-selective inhibitor of dopamine and noradrenalin transporters

Key Product Details

Description:	Non-selective inhibitor of dopamine and noradrenalin transporters
Chemical Name:	1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	276.2

View Full Technical Details for Bupropion hydrochloride

Technical Data
Citations

Biological Activity for Bupropion hydrochloride

Bupropion hydrochloride is a non-selective inhibitor of dopamine and noradrenalin transporters (K_i values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively). Also inhibits neuronal nicotinic acetylcholine receptors. Displays antidepressant activity and augments nicotine self-administration at low doses in vivo.

Compound Libraries for Bupropion hydrochloride

Bupropion hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Bupropion hydrochloride

M. Wt	276.2
Formula	C₁₃H₁₈ClNO.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	31677-93-7
PubChem ID	62884
InChi Key	HEYVINCGKDONRU-UHFFFAOYSA-N
Smiles	ClC1=CC=CC(C(C(C)NC(C)(C)C)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Bupropion hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	27.62	100
	DMSO	27.62	100

Preparing Stock Solutions for Bupropion hydrochloride

The following data is based on the product molecular weight 276.2.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.62 mL	18.10 mL	36.21 mL
5 mM	0.72 mL	3.62 mL	7.24 mL
10 mM	0.36 mL	1.81 mL	3.62 mL
50 mM	0.07 mL	0.36 mL	0.72 mL

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References for Bupropion hydrochloride

References are publications that support the biological activity of the product.

Torres Plasma membrane monoamine transporters: structure regulation and function. Nat.Rev.Neurosci. 2003 PMID: 12511858
Dwoskin Review of the pharmacology and clinical profile of bupropion, antidepressant and tobacco use cessation agent. CNS Drug Rev. 2006 PMID: 17227286
Slemmer Bupropion is a nicotinic antagonist. J.Pharmacol.Exp.Ther. 2000 PMID: 10991997