BVT 948

Name: BVT 948
Brand: Tocris Bioscience
SKU: 2176

Tocris Bioscience, part of Bio-Techne | Catalog # 2176

Citations (6)

COA / SDS

Non-competitive protein tyrosine phosphatase inhibitor

Key Product Details

Chemical Name:	4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
Purity:	≥98%
Molecular Weight:	241.25 kDa

View Full Technical Details for BVT 948

Technical Data
Citations

Biological Activity for BVT 948

BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC₅₀ = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Enhances insulin signaling in vitro and insulin tolerance in ob/ob mice in vivo. Also inhibits several cytochrome P450 isoforms (IC₅₀ <10 μM).

Technical Data for BVT 948

M. Wt	241.25 kDa
Formula	C₁₄H₁₁NO₃
Storage	Store at RT
Purity	≥98%
CAS Number	39674-97-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BVT 948

Solubility

Soluble Soluble to 50 mM in ethanol and to 50 mM in DMSO

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References for BVT 948

References are publications that support the biological activity of the product.

Liljebris et al. Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J.Pharmacol.Exp.Ther., 2004;309:711 PMID: 14747616