BX 513 hydrochloride

Name: BX 513 hydrochloride
Brand: Tocris Bioscience
SKU: 2769

Tocris Bioscience, part of Bio-Techne | Catalog # 2769

Citations (3)

COA / SDS

Selective CCR1 antagonist

Key Product Details

Description:	Selective CCR1 antagonist
Alternative Names:	VUF 2274
Chemical Name:	4-(4-Chlorophenyl)-4-hydroxy-α,α-diphenyl-1-piperidinepentanenitrile hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	481.46

View Full Technical Details for BX 513 hydrochloride

Technical Data
Citations

Biological Activity for BX 513 hydrochloride

BX 513 hydrochloride is a selective CCR1 receptor antagonist (K_i values are 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors respectively). Inhibits MIP-1α-induced intracellular calcium mobilization (IC₅₀ = 2.5 μM). Also a full inverse agonist at US28, a HCMV-encoded chemokine receptor.

Compound Libraries for BX 513 hydrochloride

BX 513 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for BX 513 hydrochloride

M. Wt	481.46
Formula	C₂₈H₂₉ClN₂O.HCl
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	1216540-18-9
PubChem ID	56972186
InChi Key	SSZWNUGWOGONQJ-UHFFFAOYSA-N
Smiles	ClC1=CC=C(C2(O)CCN(CCCC(C4=CC=CC=C4)(C#N)C3=CC=CC=C3)CC2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for BX 513 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	48.15	100
	ethanol	24.07	50

Preparing Stock Solutions for BX 513 hydrochloride

The following data is based on the product molecular weight 481.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.08 mL	10.39 mL	20.77 mL
5 mM	0.42 mL	2.08 mL	4.15 mL
10 mM	0.21 mL	1.04 mL	2.08 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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References for BX 513 hydrochloride

References are publications that support the biological activity of the product.

Ng Discovery of a novel non-peptide CCR1 receptor antagonists. J.Med.Chem. 1999 PMID: 10579830
Casarosa Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G-protein-coupled receptor. J.Biol.Chem. 2003 PMID: 12456673
Hesselgesser Identification and characterisation of small molecule functional antagonists of the CCR1 chemokine receptor. J.Biol.Chem. 1998 PMID: 9624164