C 101248

Name: C 101248
Brand: Tocris Bioscience
SKU: 8007

Tocris Bioscience, part of Bio-Techne | Catalog # 8007

Citations (1)

COA / SDS

Selective and potent inhibitor of both mouse and human THIK-1

Key Product Details

Description:	Selective and potent inhibitor of both mouse and human THIK-1
Chemical Name:	4-[1-(4-Pyridinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine
Purity:	≥98% (HPLC)
Molecular Weight:	292.3

View Full Technical Details for C 101248

Technical Data
Citations

Biological Activity for C 101248

C 101248 is a selective and potent inhibitor of both mouse and human tandem pore domain halothane-inhibited K⁺ channel 1 (THIK-1, IC₅₀ = 50 nM); it exhibits no activity against K2P family members, TREK-1 and TWIK-2, and K_v2.1. C 101248 blocks both tonic and ATP-evoked THIK-1 K⁺ currents in whole-cell patch-clamp recordings of mouse hippocampal microglia. C 101248 reduces neuroinflammation by preventing NLRP3-dependent release of IL-1β in isolated microglia.

Technical Data for C 101248

M. Wt	292.3
Formula	C₁₅H₁₂N₆O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	361368-24-3
PubChem ID	723233
InChi Key	LXADAVBNVFYEBW-UHFFFAOYSA-N
Smiles	NC1=NON=C1C2=NC3=CC=CC=C3N2CC4=CC=NC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C 101248

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	29.23	100

Preparing Stock Solutions for C 101248

The following data is based on the product molecular weight 292.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.42 mL	17.11 mL	34.21 mL
5 mM	0.68 mL	3.42 mL	6.84 mL
10 mM	0.34 mL	1.71 mL	3.42 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References for C 101248

References are publications that support the biological activity of the product.

Ossola Characterisation of C101248: a novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome. Neuropharmacology 2022 PMID: 36375694