C 75

Name: C 75
Brand: Tocris Bioscience
SKU: 2489

Tocris Bioscience, part of Bio-Techne | Catalog # 2489

Citations (9)

COA / SDS

Potent fatty acid synthase inhibitor; proapoptotic

Key Product Details

Description:	Potent fatty acid synthase inhibitor; proapoptotic
Alternative Names:	trans-C 75
Chemical Name:	(2R,3S)-Tetrahydro-4-methylene-2-octyl-5-oxo-3-furancarboxylic acid
Purity:	≥95% (HPLC)
Molecular Weight:	254.32

View Full Technical Details for C 75

Technical Data
Citations

Biological Activity for C 75

C 75 is a synthetic inhibitor of fatty acid synthase (FASN); inhibits fatty acid synthesis in vitro and in vivo. Displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits antitumor activity.

Compound Libraries for C 75

C 75 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for C 75

M. Wt	254.32
Formula	C₁₄H₂₂O₄
Storage	Store at +4°C
Purity	≥95% (HPLC)
CAS Number	191282-48-1
PubChem ID	90488767
InChi Key	VHOGWRFOUWVZQX-FBVLPHPLSA-N
Smiles	C=C([C@@H]([C@](O)=O)[C@H](CCCCCCCC)O1)C1=O.C=C([C@H](C(O)=O)[C@@H](CCCCCCCC)O2)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for C 75

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	1eq. NaOH	25.43	100
	DMSO	25.43	100

Preparing Stock Solutions for C 75

The following data is based on the product molecular weight 254.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.93 mL	19.66 mL	39.32 mL
5 mM	0.79 mL	3.93 mL	7.86 mL
10 mM	0.39 mL	1.97 mL	3.93 mL
50 mM	0.08 mL	0.39 mL	0.79 mL

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References for C 75

References are publications that support the biological activity of the product.

Thupari Chronic C75 treatment of diet-induced obese mice increases fat oxidation and reduces food intake to reduce adipose mass. Am.J.Physiol.Endocrinol.Metab.
Takahashi The anorexigenic fatty acid synthase inhibitor, C45, is a nonspecific neuronal activator. Endocrinology 2004 PMID: 14512433
Kuhajda Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc.Natl.Acad.Sci.
Zhou Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells. Cancer Res. 2003 PMID: 14612531