CaCCinh-A01

Name: CaCCinh-A01
Brand: Tocris Bioscience
SKU: 4877

Tocris Bioscience, part of Bio-Techne | Catalog # 4877

Citations (30)

COA / SDS

Calcium-activated chloride channel (CaCC) inhibitor

Key Product Details

Chemical Name:	6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
Purity:	≥99%

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Technical Data
Citations

Biological Activity for CaCCinh-A01

CaCCinh-A01 is a calcium-activated chloride channel (CaCC) inhibitor (IC₅₀ ~ 10 μM). Inhibits CaCC currents in human bronchial and intestinal cells. Also inhibits TMEM16A channels (IC₅₀ = 2.1 μM, in TMEM16A-expressing FRT cells).

Technical Data for CaCCinh-A01

Formula	C₁₈H₂₁NO₄S
Storage	Store at -20°C
Purity	≥99%
CAS Number	407587-33-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CaCCinh-A01

Solubility

Soluble Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming

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References for CaCCinh-A01

References are publications that support the biological activity of the product.

Namkung et al. TMEM16A inhibitors reveal TMEM16A as a minor component of calcium-activated chloride channel conductance in airway and intestinal epithelial cells. J.Biol.Chem., 2011;286:2365 PMID: 21084298
De La Fuente et al. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol.Pharmacol., 2008;73:758 PMID: 18083779

CaCCinh-A01

Tocris Bioscience, part of Bio-Techne | Catalog # 4877

Key Product Details

Biological Activity for CaCCinh-A01

Technical Data for CaCCinh-A01

Solubility for CaCCinh-A01

Dilution Calculator

Reconstitution Calculator

References for CaCCinh-A01

Product Documents for CaCCinh-A01

COA

Certificate of Analysis

SDS

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