Calphostin C

Name: Calphostin C
Brand: Tocris Bioscience
SKU: 1626

Tocris Bioscience, part of Bio-Techne | Catalog # 1626

Citations (55)

COA / SDS

Potent, selective and photo-dependent PKC inhibitor

Key Product Details

Description:	Potent, selective and photo-dependent PKC inhibitor
Alternative Names:	UCN 1028C,PKF 115584
Chemical Name:	(1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
Purity:	≥95% (HPLC)
Molecular Weight:	790.76

View Full Technical Details for Calphostin C

Technical Data
Citations

Biological Activity for Calphostin C

Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC₅₀ = 50 nM). Displays > 1000-fold selectivity over other protein kinases such as cAMP-dependent protein kinase and tyrosine-specific protein kinase. Inhibits cell proliferation of malignant glioma cells in light-treated conditions in vitro (IC₅₀ ~ 40 - 60 nM). Also an antagonist of the Tcf/β-catenin complex.

Technical Data for Calphostin C

M. Wt	790.76
Formula	C₄₄H₃₈O₁₄
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	121263-19-2
PubChem ID	6604893
InChi Key	SRJYZPCBWDVSGO-NHCUHLMSSA-N
Smiles	O=C1C(OC)=C(C[C@@H](C)OC(C2=CC=CC=C2)=O)C3=C4C5=C(C(OC)=CC(O)=C5C(C(OC)=C4C[C@@H](C)OC(OC6=CC=C(O)C=C6)=O)=O)C7=C(OC)C=C(O)C1=C73

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Calphostin C

References are publications that support the biological activity of the product.

Matsuzaki and Darcha In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis. PLoS One 2013 PMID: 23626717
Au Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. J.Photochem.Photobiol.B. 2006 PMID: 16829117
Kobayashi Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem.Biophys.Res.Comm.
Pollack and Kawecki The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro. J.Neurooncol. 1997 PMID: 9049854

Calphostin C

Tocris Bioscience, part of Bio-Techne | Catalog # 1626

Key Product Details

Biological Activity for Calphostin C

Technical Data for Calphostin C

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Calphostin C

Product Documents for Calphostin C

COA

Certificate of Analysis

SDS

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