Cambinol

Name: Cambinol
Brand: Tocris Bioscience
SKU: 7137

Tocris Bioscience, part of Bio-Techne | Catalog # 7137

COA / SDS

nSMase2 inhibitor

Key Product Details

Description:	nSMase2 inhibitor
Chemical Name:	2,3-Dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone
Purity:	≥98% (HPLC)
Molecular Weight:	360.43

View Full Technical Details for Cambinol

Technical Data
Citations

Biological Activity for Cambinol

Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (K_i = 7 μM; IC₅₀ ~ 7.7 μM). In vitro, Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo, Cambinol decreases tumor necrosis factor-α or interleukin-1β-induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.

Technical Data for Cambinol

M. Wt	360.43
Formula	C₂₁H₁₆N₂O₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	14513-15-6
PubChem ID	3246390
InChi Key	RVNSQVIUFZVNAU-UHFFFAOYSA-N
Smiles	OC1=C(C2=CC=CC=C2C=C1)CC3=C(C4=CC=CC=C4)NC(NC3=O)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Cambinol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	36.04	100

Preparing Stock Solutions for Cambinol

The following data is based on the product molecular weight 360.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.77 mL	13.87 mL	27.74 mL
5 mM	0.55 mL	2.77 mL	5.55 mL
10 mM	0.28 mL	1.39 mL	2.77 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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References for Cambinol

References are publications that support the biological activity of the product.

Heltweg Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 PMID: 16618762
Bilousova Suppression of tau propagation using an inhibitor that targets the DK-switch of nSMase2. Biochem.Biophys.Res.Commun. 2018 PMID: 29604274
Stepanek Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. Eur.J.Med.Chem. 2019 PMID: 30921693
Sackmann Inhibition of nSMase2 reduces the transfer of oligomeric α-synuclein irrespective of hypoxia. Front.Mol.Neurosci. 2019 PMID: 31555088
Figuera-Losada Cambinol, a novel inhibitor of neutral sphingomyelinase 2 shows neuroprotective properties. PLoS One 2015 PMID: 26010541